Quick answer
A first edition of An Inquiry into the Causes and Effects of the Variolae Vaccinae by Edward Jenner (Printed for the author by Sampson Low, 1798) is identified by: First edition, quarto, printed for the author by Sampson Low at No. 7 Berwick Street, Soho, and sold by Law, Ave-Maria Lane, and by Murray and Highley, Fleet Street.
Checklist — a true first has these:
- First edition, quarto, printed for the author by Sampson Low at No. 7 Berwick Street, Soho, and sold by Law, Ave-Maria Lane, and by Murray and Highley, Fleet Street
- Collates iv, 75, [1] pages plus 4 unnumbered leaves of plates, colour-printed in sanguine and hand-finished, engraved by William Skelton after drawings by Edward Pearce and SkeltonP-035640
- A complete first-issue copy retains its integral half-title (copies 'wanting the half-title' are a commonly noted defect) and all four platesP-035641
- The pamphlet presents 23 case histories of cowpox inoculation as protection against smallpox, published at Jenner's own expenseP-035642
- Publisher imprint reads Printed for the author by Sampson Low
- Not a book-club edition (see below)
| Author | Edward Jenner |
|---|---|
| Publisher | Printed for the author by Sampson Low |
| Year | 1798 |
| True first | — |
| Format | Hardcover (trade) |
| Key point | First edition, quarto, printed for the author by Sampson Low at No. 7 Berwick Street, Soho, and sold by Law, Ave-Maria Lane, and by Murray… |
| Book-club edition exists? | — |
The points of issue
- First edition, quarto, printed for the author by Sampson Low at No. 7 Berwick Street, Soho, and sold by Law, Ave-Maria Lane, and by Murray and Highley, Fleet Street
- Collates iv, 75, [1] pages plus 4 unnumbered leaves of plates, colour-printed in sanguine and hand-finished, engraved by William Skelton after drawings by Edward Pearce and Skelton
- A complete first-issue copy retains its integral half-title (copies 'wanting the half-title' are a commonly noted defect) and all four plates
- The pamphlet presents 23 case histories of cowpox inoculation as protection against smallpox, published at Jenner's own expense
How to confirm the first-printing statement
Publishers stated first printings differently by era. The decisive tells are a printed “First Edition/First Printing” statement, a number line whose lowest number is 1 (Random House ends at 2), or a dated first printing with no later printings listed. Paste your copyright page into the number-line decoder.
How to verify your copy, step by step
- Find the copyright page — the verso (back) of the title page.
- Confirm the first-edition statement — look for “First Edition,” “First Printing,” or the publisher’s equivalent wording.
- Check for a number line or dated printing — the lowest number present is the printing; a dated first printing with no later printings listed is the tell.
- Rule out a book-club edition — a blind-stamp on the rear board or a jacket with no printed price marks a book-club copy.
- Photograph four things — the front cover, spine, title page, and copyright page — the standard record for identification.
The dust jacket
For a collectible first edition the dust jacket matters as much as the book. Confirm the jacket is present and unclipped — the printed price should still be at the corner of the flap (a clipped corner or a price-less flap can indicate a book-club issue). First-state jackets can differ from later ones in the cover art, blurbs, or review quotations; where a specific first-state jacket point is known for this title it is noted above.
Binding & format
Where multiple bindings exist, the hardcover trade issue is usually (but not always) the precedence copy — confirm against the points above. Later printings often show cheaper cloth, thinner boards, or simplified spine stamping. A simultaneous signed or limited issue, when one exists, is a distinct state from the trade first.
Telling it from reprints & book-club editions
Jenner's own supplementary pamphlets, Further Observations on the Variolae Vaccinae (1799) and A Continuation of Facts and Observations Relative to the Variolae Vaccinae (1800), are separate later publications occasionally bound in afterward; a copy consisting only of the 1798 Inquiry under its own 1798 title page is the first edition proper.P-035643
Frequently asked questions
Is my copy of An Inquiry into the Causes and Effects of the Variolae Vaccinae a first edition?
A first edition of An Inquiry into the Causes and Effects of the Variolae Vaccinae by Edward Jenner (Printed for the author by Sampson Low) is identified by: First edition, quarto, printed for the author by Sampson Low at No. 7 Berwick Street, Soho, and sold by Law, Ave-Maria Lane, and by Murray and Highley, Fleet Street.
How do I tell the first printing from a later one?
Check the copyright page. A stated first edition, a number line ending in 1, or a dated first printing with no later printings listed is the key.
Is the book-club edition the same as the first?
Jenner's own supplementary pamphlets, Further Observations on the Variolae Vaccinae (1799) and A Continuation of Facts and Observations Relative to the Variolae Vaccinae (1800), are separate later publications occasionally bound in afterward; a copy consisting only of the 1798 Inquiry under its own 1798 title page is the first edition proper.
I have a first edition of An Inquiry into the Causes and Effects of the Variolae Vaccinae — what should I do?
First, document the copy: photograph the copyright page (the number line and any edition statement) and the dust-jacket flap. Confirm the points of issue above against your copy, and decode the printing with the free First Edition Checker. Clearing out books? I take them as a free donation and make sure collectible copies are identified, not discarded: free pickup in the Albuquerque metro (scheduled by route), the 24/7 drop box at 5445 Edith Blvd NE, or donor-paid mail-in from anywhere in the US. Questions? Call or text 505-250-3804.
Glossary
- First edition
- Every copy printed from the first setting of type. Collectors usually want the first edition, first printing (the true first).
- First printing / impression
- A single press run from that setting. The first printing is the earliest and most desirable; later printings are still the first edition but not the true first.
- Number line (printer's key)
- A row of numbers on the copyright page (e.g. 10 9 8 7 6 5 4 3 2 1). The lowest number present is the printing — a line including 1 marks a first printing (Random House deliberately ends at 2).
- Points of issue
- Specific physical details — a stated edition, a number line, a typo, a jacket state — that identify the true first printing.
- Book-club edition (BCE)
- A reprint made for a book club. Tells include a blind-stamped dot or square on the rear board and a dust jacket with no printed price. Not the true first.
- First thus
- The first appearance of a particular version (first paperback, first illustrated, first U.S. printing) — a first of that kind, not the first edition of the work.
Related first editions
- On the Mode of Communication of Cholera — John Snow
- An Account of the Foxglove — William Withering
- Hereditary Genius: An Inquiry into Its Laws and Consequences — Francis Galton
- The Principles of Psychology — William James
- Incidents in the Life of a Slave Girl — Harriet Jacobs
- Clotel; or, The President's Daughter — William Wells Brown
- Narrative of Sojourner Truth — Sojourner Truth
- The Future of the American Negro — Booker T. Washington
How to cite this page
New Mexico Literacy Project. “Is An Inquiry into the Causes and Effects of the Variolae Vaccinae by Edward Jenner a First Edition? Points of Issue.” NMLP First-Edition Identification Reference. Reviewed 4 July 2026. Retrieved from https://newmexicoliteracyproject.org/first-edition/an-inquiry-into-the-causes-and-effects-of-the-variolae-vacci. Licensed CC BY 4.0 — part of the open Canonical First-Edition Points of Issue dataset (DOI 10.5281/zenodo.21184548).